Valacyclovir during pregnancy

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  1. -Jet Well-Known Member

    Valacyclovir during pregnancy


    Valacyclovir belongs to the class of medications known as antivirals. It is used to treat a viral infection affecting the skin known as shingles (herpes zoster). It is also used to treat cold sores, and to treat and prevent recurrences of genital herpes. It works by interfering with the way the virus reproduces. Valacyclovir works by stopping the virus from multiplying and spreading to nearby healthy cells. It does not cure shingles, cold sores, or genital herpes, but it does help the sores to heal more quickly, and it relieves pain and discomfort. When used to prevent recurrences of herpes, it also reduces the risk of transmission (spreading) of the infection to others. Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. Questions about personal health should always be referred to a physician or other health care professional. 24, 2010 (Health Day News) -- Pregnant women who take antiviral drugs against the herpes virus should not worry that their use will cause birth defects, Danish researchers report. More than 1 percent of women develop herpes simplex during the first trimester of pregnancy. And while the use during pregnancy of antiviral drugs such as acyclovir (Zovirax), valacyclovir (Valtrex) and famciclovir (Famvir) are believed to be safe, data on their use in early pregnancy has been limited, the researchers noted. But the new analysis suggests that "pregnant women needing treatment for a herpes infection in the first trimester can use antivirals without concern about birth defect risk," said lead researcher Dr. Bjorn Pasternak, from the department of epidemiology research at the Statens Serum Institut in Copenhagen. Acyclovir was the most commonly used antiviral, and should be the antiviral drug of choice in the treatment of herpes infections in early pregnancy, Pasternak said."More research is however needed with regard to use of antiviral drugs in pregnancy and the risk of other adverse fetal outcomes, such as growth restriction, preterm birth and spontaneous abortion," he said.

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    The primary goal of genital herpes management during pregnancy is to. Acyclovir Zovirax and valacyclovir Valtrex are the drugs most. During the years 1995 to 1999, the manufacturer of valacyclovir maintained its pregnancy registry, and. Answer Studies have shown that the use of acyclovir or valacyclovir is not associated with an increase in birth defects. Limited data exist for famciclovir and therefore it would not be considered a first-line choice for treatment of herpes during pregnancy.

    Most women think that having herpes during pregnancy is a fairly straightforward matter: If you have any sores when you go into labor, you’ll simply deliver by Cesarean section to avoid infecting your baby. Yet the issue is much more complicated than is often perceived. For example, herpes is far more prevalent than is generally recognized, and many people don’t know they’re infected or that they can contract the virus from a partner who has no symptoms. What’s more, few people realize that contracting herpes during pregnancy can be very dangerous to the baby. Here’s what every pregnant woman needs to know about this very common virus: RELATED: 17 Tips for a Healthy Pregnancy Your chances of having herpes may be greater than you think... According to the Centers for Disease Control and Prevention, 16.2 percent of U. adults—1 in 6—have genital herpes caused by herpes simplex virus 2, or HSV-2. However, when you factor in the number of people who have genital herpes caused by HSV-1, the strain typically associated with fever blisters of the mouth, the number skyrockets to approximately 1 in 3, says David Kimberlin, M. JAMAJAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) The prevalence odds ratios (95% confidence intervals [CIs]) are adjusted for univariate risk factors (e Table 1). Association Between Oral Acyclovir, Valacyclovir, and Famciclovir Use in Pregnancy and Major Birth Defects in a Cohort of 837 795 Live Births in Denmark, January 1, 1996, to September 30, 2008Yawn BP, Saddier P, Wollan PC, St Sauver JL, Kurland MJ, Sy LS. The sum of birth defects from the subgroups is larger than the number of birth defects in overall analyses in which only the first birth defect was counted because some participants had birth defects from more than 1 subgroup. A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. 2007;82(11):1341-134917976353Pub Med Google Scholar Crossref Tyring SK, Baker D, Snowden W. Valacyclovir for herpes simplex virus infection: long-term safety and sustained efficacy after 20 years' experience with acyclovir. 2002;186:(suppl 1) S40-S4612353186Pub Med Google Scholar Crossref Moore HL Jr, Szczech GM, Rodwell DE, Kapp RW Jr, de Miranda P, Tucker WE Jr. Preclinical toxicology studies with acyclovir: teratologic, reproductive and neonatal tests. 1983;3(6):560-5686662297Pub Med Google Scholar Crossref Chahoud I, Stahlmann R, Bochert G, Dillmann I, Neubert D. Gross-structural defects in rats after acyclovir application on day 10 of gestation. 1988;62(1):8-143190462Pub Med Google Scholar Crossref Stone KM, Reiff-Eldridge R, White AD, et al. Pregnancy outcomes following systemic prenatal acyclovir exposure: conclusions from the international acyclovir pregnancy registry, 1984-1999. 2004;70(4):201-20715108247Pub Med Google Scholar Crossref Ratanajamit C, Vinther Skriver M, et al. Adverse pregnancy outcome in women exposed to acyclovir during pregnancy: a population-based observational study. 2003;35(4):255-25912839155Pub Med Google Scholar Crossref Wilton LV, Pearce GL, Martin RM, Mackay FJ, Mann RD.

    Valacyclovir during pregnancy

    Common Side Effects of Valtrex Valacyclovir Hydrochloride Drug., Safety of antiviral medication for the treatment of herpes during.

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  4. Apr 11, 2012. Exposure to PMTCT ARVs and acyclovir after maternal administration of valacyclovir during pregnancy and postpartum to women co-infected.

    • Infant Safety during and after Maternal Valacyclovir Therapy in. - PLOS.
    • Safety of antiviral medication for the treatment of herpes..
    • Acyclovir, Valacyclovir in First Trimester Not Linked to Major Birth..

    Background The antiviral agents acyclovir Zovirax, valacyclovir. herpes simplex virus infection during the first trimester of pregnancy, and. Aug 25, 2010. Acyclovir, valacyclovir, and famciclovir are antiviral agents used in the. There are no published data on valacyclovir in early pregnancy and. Advice and warnings for the use of Valacyclovir Valtrex during pregnancy. FDA Pregnancy Category B - No proven risk in humans.

     
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