This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 7, 2009 -- Besides treating depression, the antidepressant Paxil may affect personality traits in positive ways, a new study suggests. Researchers say Paxil and likely other antidepressants in the class of drugs called selective serotonin reuptake inhibitors (SSRIs) may improve higher levels of neuroticism and lower levels of extraversion that are commonly seen with depression. Neuroticism is characterized as being inclined to have negative emotions such as anxiety, hostility, self-consciousness, impulsivity, and sensitivity to stress. Extraversion refers to being inclined to have positive emotions, assertiveness, and gregariousness. In a placebo-controlled trial involving 240 adults with moderate to severe depression, 120 patients in the study took Paxil, 60 underwent cognitive therapy, and 60 took placebos for eight weeks. In weeks 9-16, half of the participants on placebo were given Paxil. Prozac and Zoloft are powerful prescription medications used to treat depression and other issues. The generic version of Prozac is fluoxetine, while the generic version of Zoloft is sertraline hydrochloride. Both drugs are selective serotonin reuptake inhibitors (SSRIs). Serotonin is a naturally occurring chemical that produces a feeling of well-being. These drugs work by influencing serotonin levels in your brain. By balancing chemicals in your brain, these drugs will likely improve your mood and appetite. They can also enhance your energy levels and help you sleep better. Both medications can reduce anxiety, fear, and compulsive behaviors. 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